What are ceramides? Benefits, uses, side effects and more
These waxy lipids can play a vital role in skin health. Learn more about ceramides and the products that contain them.
Ceramides are fatty acids that occur naturally in the outer layer of skin. They can help the skin stay hydrated and protected from wear and tear. Read on to discover more about the power of ceramides in skin care.
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What are ceramides and what do ceramides do?
Ceramides are a type of lipid or fatty acid that occur naturally in the skin. In fact, they make up about 50 percent of all lipids in the outer layer of the skin. Ceramides may be vital in helping to keep skin protected from external factors (think pollution and toxins), and they can also help the skin retain water.
In skin care products, ceramides help limit moisture loss, which can keep skin hydrated. Moisturizers, including those that contain ceramides, can be used to help manage symptoms of soriasis y eczema. A lack of ceramides in the skin can contribute to dryness and inflammation.
Types of ceramides
There are many different classes of ceramides, but they're not all available in skin care products. Some common ones available in many drugstores include:
- Ceramide 1, also called ceramide EOP
- Ceramide 2, also called ceramide NS or NG
- Ceramide 3, also called ceramide NP
- Ceramide 6-II, also called ceramide AP
Discuss the best ceramide with a health care provider.
How to use ceramides
As with any product, follow the instructions on the packaging first, and speak with a health care provider before starting any new treatment. But here are some general reasons to use ceramides in a skin care routine:
- Itching from dry skin can be bothersome. Products with ceramides, such as cleansers, creams and serums, are often used to help hydrate dry skin.
- When dealing with seasonal dryness on otherwise normal skin, consider a lotion with a ceramide. For extraordinarily dry skin or for those who are perimenopausal or over the age of 50, consider a cream-based ceramide product instead.
- Apply moisturizer with ceramides after getting out of the shower. Creams and moisturizers spread more easily and absorb more moisture when used on damp skin.
- A moisturizer with ceramide can be applied daily, although pay attention to skin needs, especially as the seasons change. Talk to a health care provider about any concerns.
Ceramide side effects
There are a few known side effects of using ceramides. Check the product label for directions, use instructions and safety information.
To test for a reaction, apply a small amount of product containing ceramide to the skin. If no reaction occurs, the amount can be increased. If there is a change, immediately contact a health care provider. Ceramides are generally considered to be safe for topical use.
What can’t mix with ceramides?
Ceramides can typically work with almost any other skin care ingredient, but speak to a health care provider before mixing.
Do ceramides get rid of wrinkles?
Wrinkles are associated with aging and external stresses on the skin. Since ceramides help protect the skin's barrier, increase hydration and help the skin hold structure, they can help reduce the appearance of wrinkles.
Is it OK to use ceramides every day?
Ceramides are generally considered to be gentle and safe for everyday use.
Este contenido es solo para fines informativos y no constituye un asesoramiento médico. Consulte con su proveedor de servicios de salud antes de tomar alguna vitamina o suplemento y antes de comenzar o cambiar alguna práctica relacionada con el cuidado de su salud.
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FOR CERAMIDES ARE FATTY ACIDS SOURCE: Coderch L, López O, de la Maza A, et al. Ceramides and skin function. American Journal of Clinical Dermatology. 2003;4(2):107-29.
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FOR HELPING TO KEEP SKIN PROTECTED FROM EXTERNAL FACTORS, HELP THE SKIN RETAIN WATER SOURCE: Bzioueche H, Tamelghaghet M, Chignon-Sicard B, et al. Ceramide AD™ restores skin integrity and function following exposure to house dust mite. International Journal of Molecular Sciences. 2023;24(11):9234.
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FOR CERAMIDES HELP LIMIT MOISTURE LOSS SOURCE: Spada F, Barnes TM, Greive KA. Skin hydration is significantly increased by a cream formulated to mimic the skin's own natural moisturizing systems. Clinical, Cosmetic and Investigational Dermatology. 2018;11:491-497.
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FOR CERAMIDES HELP MANAGE SYMPTOMS OF PSORIASIS SOURCE: National Psoriasis Foundation. Must-have lotions. Published January 16, 2025.
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FOR LACK OF CERAMIDES IN THE SKIN CAN CONTRIBUTE TO DRYNESS AND INFLAMMATION SOURCE: Yong TL, Zaman R, Rehman N, et al. Ceramides and skin health: new insights. Experimental Dermatology. 2025;34:e70042.
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FOR TYPES OF CERAMIDES SOURCE 1: National Center for Biotechnology Information. PubChem compound summary for CID 5282311, 3-dehydroxy ceramide 1. PubChem. Accessed September 4, 2025.
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FOR TYPES OF CERAMIDES SOURCE 2: Cosmetic Ingredient Review. Safety assessment of ceramides as used in cosmetics. Published April 6, 2015.
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FOR ITCHING FROM DRY SKIN CAN BE BOTHERSOME SOURCE: American Academy of Dermatology Association. Dry skin: Diagnosis and treatment. Consultado el 4 de septiembre de 2025.
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FOR EXTRAORDINARILY DRY SKIN, PERIMENOPAUSAL OR OVER THE AGE OF 50 SOURCE: American Academy of Dermatology Association. How to pick the right moisturizer for your skin. Updated January 25, 2022.
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FOR APPLY MOISTURIZER WITH CERAMIDES AFTER GETTING OUT OF THE SHOWER SOURCE: American Academy of Dermatology Association. How to pick the right moisturizer for your skin. Updated January 25, 2022.
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FOR A MOISTURIZER WITH CERAMIDE CAN BE APPLIED DAILY SOURCE: Spada F, Harrison IP, Barnes TM, et al. A daily regimen of a ceramide-dominant moisturizing cream and cleanser restores the skin permeability barrier in adults with moderate eczema: A randomized trial. Dermatologic Therapy. 2021;34(4):e14970.
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FOR A FEW KNOWN SIDE EFFECTS OF USING CERAMIDES SOURCE: Ho VPY, Ma E, Liew HM, et al. Comparing the potential for irritation of a ceramide-based moisturizer with a urea-based moisturizer for pediatric atopic dermatitis. Dermatologic Therapy. 2020;10(4):807-813.
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FOR TEST FOR A REACTION. American Academy of Dermatology. How to test skin care products. Updated August 10, 2021.
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FOR CERAMIDES ARE GENERALLY CONSIDERED TO BE SAFE FOR TOPICAL USE: Spada F, Barnes TM, Greive KA. Skin hydration is significantly increased by a cream formulated to mimic the skin's own natural moisturizing systems. Clinical, Cosmetic and Investigative Dermatology. 2018;11:491-497.
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FOR CERAMIDES CAN TYPICALLY WORK WITH ALMOST ANY OTHER SKIN CARE INGREDIENT SOURCE: CeraVe. What ingredients can you mix with ceramides in skin care? Consultado el 4 de septiembre de 2025.
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FOR WRINKLES ARE ASSOCIATED WITH AGING AND EXTERNAL STRESSES ON THE SKIN SOURCE: MedlinePlus. Aging changes in skin. Updated May 15, 2024.
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FOR HELP REDUCE THE APPEARANCE OF WRINKLES SOURCE: Spada F, Barnes TM, Greive KA. Skin hydration is significantly increased by a cream formulated to mimic the skin's own natural moisturizing systems. Clinical, Cosmetic and Investigative Dermatology. 2018;11:491-497.
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FOR CERAMIDES ARE GENERALLY CONSIDERED TO BE GENTLE AND SAFE FOR EVERYDAY USE SOURCE: Spada F, Harrison IP, Barnes TM, et al. A daily regimen of a ceramide-dominant moisturizing cream and cleanser restores the skin permeability barrier in adults with moderate eczema: A randomized trial. Dermatologic Therapy. 2021;34(4):e14970.